Endocrine Abstracts

Polycystic ovary syndrome (PCOS) is characterized by anovulation, hyperandrogenemia, and polycystic ovaries. Although the etiology of PCOS is poorly understood, the common denominator is a disturbance in the selection of the dominant follicle. TGFβ family members, such as anti-Müllerian hormone (AMH) and bone morphogenetic proteins (BMPs), suppress FSH sensitivity. Therefore their signaling pathway may contribute to the aberrant follicle development in PCOS women. We...

Polycystic ovary syndrome (PCOS) is characterized by anovulation, elevated levels of circulating androgens and polycystic ovaries. Although the etiology of PCOS is poorly understood, the common denominator is a disturbance in the selection of the dominant follicle. In PCOS women serum Anti-Müllerian Hormone (AMH) levels are elevated. Since AMH reduces FSH sensitivity of growing follicles, the elevated AMH levels in PCOS patients may contribute to the disturbed follicle se...